Cartilage Care (30 caps)

Research

• The efficacy of UC-II in supporting joint function in healthy subjects was studied in a randomized, double-blind, placebo-controlled study of 55 people. Subjects took 40 mg of UC-II or placebo for 120 days. The physical stressor was induced by placing subjects on a standardized stepmill procedure until they complained of knee discomfort of at least 5 on a 0-10 point Likert scale. While on the stepmill, the “time to onset of discomfort” was measured. When subjects got off the stepmill the “time to offset of discomfort” was measured. Goniometry was used to assess the knee range of motion.
• The average knee extension at day 120 was significantly greater for people taking UC-II compared to placebo. Furthermore, the UC-II group demonstrated a statistically significant increase in average knee extension at day 90 and day 120 compared to baseline.
• The minimum time to onset of joint discomfort compared to baseline was significantly greater in the UC-II group at day 90 and day 120 while no significant changes were observed in the placebo group. Comparison between groups did not reach statistical significance.
• The percent change in maximum time to offset of discomfort in the UC-II group showed greater statistically significant reductions compared to baseline of up to 31.9% at day 60; 51.1% at day 90; and 51.9% at day 120. Comparisons between groups did not reach statistical significance.
• In a randomized, double-blind, clinical study, 52 people with osteoarthritis of the knee took 40 mg of UC-II or 1,500 mg of glucosamine + 1,200 mg of chondroitin for 90 days. UC-II significantly decreased joint pain, discomfort and immobility compared to baseline using three different assessment tools: WOMAC, VAS and Lequesne functional index.UC-II reduced WOMAC score by 33%. Glucosamine + chondroitin reduced WOMAC score by 14%.UC-II reduced VAS score by 40%. Glucosamine + chondroitin reduced VAS score by 15%.UC-II reduced Lequesne score by 20%. Glucosamine + chondroitin reduced Lequesne score by 6%.
• In two identically, designed, randomized, double-blind, placebo-controlled clinical studies, a total of 186 subjects with osteoarthritis of the knee took 40 mg of UC-II or 1,500 mg of glucosamine + 1,200 mg chondroitin or placebo for 180 days. UC-II significantly improved joint function, mobility and flexibility compared to placebo using three different assessment tools: WOMAC, VAS, and Lequesne functional index. UC-II significantly reduced overall WOMAC score at day 180 compared to placebo. UC-II significantly reduced total Lequesne and mean VAS scores day 180 compared to placebo. Glucosamine + Chondroitin did not achieve statistical significance in any of the clinical outcomes compared to placebo.
• In a human pilot study, five women with osteoarthritis took 40 mg of UC-II a day for 42 days. UC-II significantly reduced pain, morning stiffness and stiffness following periods of rest. Average reduction of pain was 26%.
• Several in-vivo studies have demonstrated that MSM possesses selective anti-inflammatory activity. In a study examining the effect of MSM on murine macrophages, MSM demonstrated the ability to inhibit the expression of inflammatory markers through the suppression of iNOS and Cox-2 genes. MSM was also shown to strongly inhibit the inflammatory cytokines IL-6 and TNF, both key in producing an inflammatory response to acute injury.
• In a randomized, double-blind, parallel, placebo-controlled study of oral glucosamine, Methylsulfonylmethane and their combination in osteoarthritis, 118 patients were randomized to receive placebo, 500mg Glu+ 500mg of MSM or combo of 500 mg Glu+500mg MSM for 12 wks. Glu, MSM and their combination produced analgesic and anti-in ammatory effect. VAS, Lesquene index and consumption of rescue meds measured.

References

1. Lugo JP, et al. J Int Soc Sports Nutr. 2013; 10:48.
2. Crowley DC, et al. Int J Med Sci. 2009; 6:312-321.
3. Saiyed ZM, et al. Presented at Scripps 12th Annual Natural Supplements Meeting, 2015, San Diego. CA.
4. Bagchi D, et al. Int J Clin Pharm Res. 2002; 22:101-110.
5. Belcaro G, et al., Panminerva Medica. 2010; 52(2 Suppl 1).55-62.
6. Ammon, H. P., et al. J Ethnopharmacol. 1993; 38(2-3):113-119
7. Jurenka J.S. Altern. Med. Rev. 2009; 14:141-153.
8. Kidd P.M., Alt. Med. Rev. 2009; 14:226-246.
9. Semalty A., et al. Fitoterapia. 2010; 81:306-314.
10. Belcaro G, et al. Panminerva Medica. 2010; 52(2 Suppl 1):55-62.
11. Belcaro G, et al. Alter Med Rev. 2010; 15(4):337-44.
12. Usha PR, et al. Clin Drug Invest 2004; 24(6):353-363

Suggested Use

Take 1 capsule daily, with a meal, or as directed by your health practitioner. Store in a cool dry place.

Warnings

If you are pregnant, nursing, or taking any medications, consult your health practitioner before use. Discontinue use and consult health practitioner if any adverse reactions occur. Keep out of reach of children. Use only if safety seal is intact.