Patient One CT Joint Care supplies a blend of traditional herbs along with flavonoids and enzymes that support joint function and comfort. This formula provides turmeric, Boswellia, ginger, devil's claw and yucca extracts along with quercetin and bromelain. Black pepper extract is included to support enhanced absorption of turmeric. CT Joint Care's complementary combination of ingredients is formulated to promote soothing support for joint discomfort and help maintain a healthy inflammatory response.

Key Ingredients

Turmeric’s active constituent curcumin acts as an orchestrator of whole body inflammatory response, influencing pro-inflammatory COX enzymes, their transcription factors and gene expression. However, it has been found that the therapeutic effectiveness of curcumin is often limited due to its poor absorption from the GI tract. When taken orally only traces appear in the blood, whereas most of the dose is excreted though the feces. Our formula includes Bioperine®, a patented extract derived from the common black pepper fruit that contains the alkaloid piperine. Black pepper has been shown to enhance the bioavailability and promote absorption of curcumin both in pre-clinical studies and in studies on human volunteers.

Bosellia Serrata is an ayurvedic herb, and its principle constituents—boswellic acid and alpha-boswellic acid—may help maintain healthy leukotriene metabolism by reducing the activity of the enzyme 5-lipoxygenase. In a randomized, double-blind, placebo-controlled trial, Boswellia extract produced statistically significant and clinically relevant decreases in knee discomfort, increases in knee flexion, and increases in walking distance.

Bromelain, an enzyme extracted from the stem and fruit of the pineapple plant, helps  modulate the inflammatory response. Its action is in part a result of inhibiting the generation of bradykinin at the inflammatory site via depletion of the plasma kallikrein system, as well as limiting the formation of fibrin by reduction of clotting cascade intermediates. Research suggests that bromelain reduces leukocyte migration into inflamed areas and prevents firm adhesion of leukocytes to blood vessels at the site of inflammation. Bromelain also has been found to enhance the absorption of quercetin, an active bioflavonoid also included in this formula. Quercetin, which belongs to a class of water-soluable plant pigments that cannot be produced in the human body, supports healthy mast cell function. It has been found to moderate pro-inflammatory pathways by inhibiting inducible ICAM-1 expression.

Devil’s Claw extract supports immune mediator activity. It promotes both healthy COX-2 and 5-lipoxygenase enzyme activity. Devil’s claw is included to provide added support for joint flexibility, function and comfort, in part by maintaining healthy eicosanoid metabolism. A review of 12 human studies indicates that devil’s claw may reduce mild discomfort and promote musculoskeletal function. Ginger root (Zingiber officinale) contains phytochemicals and has been studied for its effects on inflammatory mediator biosynthesis. The benefit of ginger has been scientifically proven by its potential inhibitory effect in reducing prostaglandin synthesis and leukotriene biosynthesis. Yucca schidigera is a plant native to Mexico and contains several physiologically active phytochemicals. Used in traditional practices by Native Americans, yucca is a rich source of steroidal saponins. It is believed that saponins may promote comfort by suppressing intestinal protozoa which may have a role in joint inflammation. Yucca is also a rich source of polyphenolics, including resveratrol and a number of other stilbenes, which help modulate inflammation.